Subsequently, serial measures of FTV during treatment are used in the adaptive randomization engine of the I-SPY 2 trial, designed to accelerate the evaluation of novel agents for breast cancer 8.
#Eyespy medai pa trial#
Results from the I-SPY 1 TRIAL (CALGB 150007/ACRIN 6657) found that functional tumor volume (FTV) predicted pathologic complete response (pCR) and recurrence-free survival 6, 7. Among imaging methods, magnetic resonance imaging (MRI) is the most accurate for assessing tumor response to NAC 1, 2, 3, 4, 5. Additionally, the improvements in prediction were more notable when analysis was conducted according to cancer subtype.Īn important advantage of neoadjuvant chemotherapy (NAC) over adjuvant therapy for locally advanced breast cancer is the ability to monitor treatment response, which allows informed adjustment of the treatment plan. Multi-feature MRI analysis improved pCR prediction over analysis of any individual feature that we examined. Results showed analysis with combined features achieved higher AUCs than analysis with any feature alone. A total of 384 patients (median age: 49 y/o) were included.
#Eyespy medai pa full#
The full cohort was stratified by hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status (positive or negative). Predictive performance was estimated using the area under the receiver operating characteristic curve (AUC). Logistic regression analysis was used to study the relationship between MRI variables and pathologic complete response (pCR).
Four features were quantitatively calculated in each MRI exam: functional tumor volume, longest diameter, sphericity, and contralateral background parenchymal enhancement. The purpose of this retrospective study is to test if prediction models combining multiple MRI features outperform models with single features. Npj Breast Cancer volume 6, Article number: 63 ( 2020)ĭynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). May Lose Value.Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL Investment management and related products and services provided to a “municipal entity” or “obligated person” regarding “proceeds of municipal securities” (as such terms are defined in the Act) will be provided by PNC Capital Advisors. PNC Bank is not registered as a municipal advisor under the Dodd-Frank Wall Street Reform and Consumer Protection Act (“Act”).
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